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Statement of Use of Apolipoprotein E Testing for Alzheimer Disease JAMA 274:1627-1629, Farrer,L.A.,et al, 1995 See this aricle in Pubmed Article Abstract There is general consensus that APOEe4 is strongly associated with AD and that when present may represent an important risk factor for the disease. However,at the present time it is not recommended for use in routine clinical diagnosis nor should it be used for predictive testing.Studies to date indicate that the APOE genotype alone does not provide sufficient sensitivity or specificity to allow genotyping to be used as a diagnostic test.Because AD develops in the absence of APOE e4 and because many with APOE e4 seem to escape disease,genotyping is also not recommended for use as a predictive genetic test.The results of collaborative study underway will clarify some of these issues.Whether APOE genotypes have other uses in the management of AD will become apparent over the next few years.

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